Clinical Applications

The majority of my research collaborations to date are with researchers on the Pulmonary and Critical Care Medicine team at Weill Cornell Medicine (WCM). Other long-term research experiences includes applications within neurology (cognitive decline/brain volumes), neuroepigenetics (effects of sugar consumption), canine genomics, and associations with air pollution and kidney disease.

This is a selected list of clinical application manuscripts I’ve co-authored. A full list of published manuscripts and papers-under-review is available on my CV.

*Indicates authors contributed equally to the work.

Selected Clinical Application Publications

Katherine L. Hoffman, Floriana Milazzo, Nicholas T. Williams, Hillary Samples, Mark Olfson, Ivan Diaz, Lisa Doan, Magdalena Cerda, Stephen Crystal, Kara E. Rudolph. Independent and joint contributions of physical disability and chronic pain to incident opioid use disorder and opioid overdose among medicaid patients. Psychological Medicine. Published online 2023:1-12. doi:10.1017/S003329172300332X

Edward J. *Schenck, Katherine L. *Hoffman, Clara Oromendia, Elizabeth Sanchez, Eli J. Finkelsztein, Kyung Sook Hong, Joseph Kabariti, Lisa K. Torres, John S. Harrington, Ilias I. Siempos, Augustine M. K. Choi, Thomas R. Campion. A Comparative Analysis of the Respiratory Subscore of the Sequential Organ Failure Assessment Scoring System. Annals of the American Thoracic Society. 2021;18(11):1849-1860. doi:10.1513/AnnalsATS.202004-399OC

Luis G. *Gómez-Escobar, Katherine L. *Hoffman, Justin J. Choi, Alain Borczuk, Steven Salvatore, Sergio L. Alvarez-Mulett, Manuel D. Galvan, Zhen Zhao, Sabrina E. Racine-Brzostek, He S. Yang, Heather W. Stout-Delgado, Mary E. Choi, Augustine M. K. Choi, Soo Jung Cho, Edward J. Schenck. Cytokine signatures of end organ injury in COVID-19. Scientific Reports. 2021;11(1):12606. doi:10.1038/s41598-021-91859-z

Edward J. Schenck, Katherine Hoffman, Parag Goyal, Justin Choi, Lisa Torres, Kapil Rajwani, Christopher W. Tam, Natalia Ivascu, Fernando J. Martinez, David A. Berlin. Respiratory Mechanics and Gas Exchange in COVID-19–associated Respiratory Failure. Annals of the American Thoracic Society. 2020;17(9):1158-1161. doi:10.1513/AnnalsATS.202005-427RL

Lisa K. Torres, Katherine L. Hoffman, Clara Oromendia, Ivan Diaz, John S. Harrington, Edward J. Schenck, David R. Price, Luis Gomez-Escobar, Angelica Higuera, Mayra Pinilla Vera, Rebecca M. Baron, Laura E. Fredenburgh, Jin-Won Huh, Augustine M. K. Choi, Ilias I. Siempos. Attributable mortality of acute respiratory distress syndrome: A systematic review, meta-analysis and survival analysis using targeted minimum loss-based estimation. Thorax. 2021;76(12):1176-1185. doi:10.1136/thoraxjnl-2020-215950

David R. Price, Katherine L. Hoffman, Clara Oromendia, Lisa K. Torres, Edward J. Schenck, Mary E. Choi, Augustine M. K. Choi, Rebecca M. Baron, Jin-Won Huh, Ilias I. Siempos. Effect of Neutropenic Critical Illness on Development and Prognosis of Acute Respiratory Distress Syndrome. American Journal of Respiratory and Critical Care Medicine. 2021;203(4):504-508. doi:10.1164/rccm.202003-0753LE

David R. Price, Katherine L. Hoffman, Elizabeth Sanchez, Augustine M. K. Choi, Ilias I. Siempos. Temporal trends of outcomes of neutropenic patients with ARDS enrolled in therapeutic clinical trials. Intensive Care Medicine. 2021;47(1):122-123. doi:10.1007/s00134-020-06263-4

William Z. Zhang, Katherine L. Hoffman, Kristen T. Schiffer, Clara Oromendia, Michelle C. Rice, Igor Barjaktarevic, Stephen P. Peters, Nirupama Putcha, Russell P. Bowler, J. Michael Wells, David J. Couper, Wassim W. Labaki, Jeffrey L. Curtis, Meilan K. Han, Robert Paine, Prescott G. Woodruff, Gerard J. Criner, Nadia N. Hansel, Ivan Diaz, Karla V. Ballman, Kiichi Nakahira, Mary E. Choi, Fernando J. Martinez, Augustine M. K. Choi, Suzanne M. Cloonan. Association of plasma mitochondrial DNA with COPD severity and progression in the SPIROMICS cohort. Respiratory Research. 2021;22(1):126. doi:10.1186/s12931-021-01707-x

Edward J. Schenck, Katherine L. Hoffman, Marika Cusick, Joseph Kabariti, Evan T. Sholle, Thomas R. Campion. Critical carE Database for Advanced Research (CEDAR): An automated method to support intensive care units with electronic health record data. Journal of Biomedical Informatics. 2021;118:103789. doi:10.1016/j.jbi.2021.103789

10.

Chang Su, Katherine L. Hoffman, Zhenxing Xu, Elizabeth Sanchez, Ilias I. Siempos, John S. Harrington, Alexandra C. Racanelli, Maria Plataki, Fei Wang, Edward J. Schenck. Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome. Critical Care Explorations. 2021;3(12):e0589. doi:10.1097/CCE.0000000000000589

11.

William Z. Zhang, Michelle C. Rice, Katherine L. Hoffman, Clara Oromendia, Igor Z. Barjaktarevic, J. Michael Wells, Annette T. Hastie, Wassim W. Labaki, Christopher B. Cooper, Alejandro P. Comellas, Gerard J. Criner, Jerry A. Krishnan, Robert Paine, Nadia N. Hansel, Russell P. Bowler, R. Graham Barr, Stephen P. Peters, Prescott G. Woodruff, Jeffrey L. Curtis, Meilan K. Han, Karla V. Ballman, Fernando J. Martinez, Augustine Mk Choi, Kiichi Nakahira, Suzanne M. Cloonan, Mary E. Choi, SPIROMICS Investigators. Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort. JCI insight. 2020;5(3):133984. doi:10.1172/jci.insight.133984

12.

Aneela Rahman, Eva Schelbaum, Katherine Hoffman, Ivan Diaz, Hollie Hristov, Randolph Andrews, Steven Jett, Hande Jackson, Andrea Lee, Harini Sarva, Silky Pahlajani, Dawn Matthews, Jonathan Dyke, Mony J. de Leon, Richard S. Isaacson, Roberta D. Brinton, Lisa Mosconi. Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study. Neurology. 2020;95(2):e166-e178. doi:10.1212/WNL.0000000000009781

13.

David R. *Price, Elisa *Benedetti, Katherine L. Hoffman, Luis Gomez-Escobar, Sergio Alvarez-Mulett, Allyson Capili, Hina Sarwath, Christopher N. Parkhurst, Elyse Lafond, Karissa Weidman, Arjun Ravishankar, Jin Gyu Cheong, Richa Batra, Mustafa Büyüközkan, Kelsey Chetnik, Imaani Easthausen, Edward J. Schenck, Alexandra C. Racanelli, Hasina Outtz Reed, Jeffrey Laurence, Steven Z. Josefowicz, Lindsay Lief, Mary E. Choi, Frank Schmidt, Alain C. Borczuk, Augustine M. K. Choi, Jan Krumsiek, Shahin Rafii. Angiopoietin 2 Is Associated with Vascular Necroptosis Induction in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome. The American Journal of Pathology. 2022;192(7):1001-1015. doi:10.1016/j.ajpath.2022.04.002